4.0. DISCUSSION

The used of previous numerous experimental trial done with livestock was very helpful to reduce the number of companion animal to demonstrated the efficiency of the scientifically blend of polyphenols to improve and treat osteoarthritis. However the study was show several limitations due to the variation of age, sex, breed, and initial prognostic. Regardless of the initial differences, all dog response very well to the presence of precise blend of polyphenols that are in a patent pending process. The results show also the speed of the response upon each animal and the quality life given back to each dog. The results obtain was even better than conventional treatment that was much more aggressive on animal. Furthermore the speed of the response was so different than all others type of nutrients such as glucosamine, chondroitin and MSM.

Inflammation drives majority of disease development. Mounting evidence reveals that phytochemical superfamily is fighting against inflammatory disease. Mirroring and complementing physiological conditions, phytochemicals target multiple signaling pathways by their antioxidant actions and antagonizing proinflammatory pathways but also strengthening the anti-inflammatory arm. Taken together with many intensive research efforts, bioactive phytochemicals in functional foods bring a new era of health promotion.

The bulk of published data illustrated the emerging and promising role of polyphenolic compounds as therapeutic tools in inflammatory diseases including osteoarthritis due to aging. The proper blend of polyphenols is key in the solution. Polyphenols appear to be important metabolic modulators by virtue of their ability to influence several cellular pathways and molecules, that have been reported as potential targets for polyphenolic compounds. However, open questions hamper the clinical use of these natural compounds. It must be noted that interactions between intracellular signaling pathways and polyphenols could have unpredictable outcomes depending on the cell type, the disease studied, and the stimulus applied. An additional crucial point concerns the consequences of the interaction or the synergistic effects between different polyphenols compounds as they could have on various intracellular targets. Further work will need to fully elucidate the molecular mechanisms of action of polyphenols in several physiological processes in order to yield important insights into their prophylactic and therapeutic uses.

The authors gratefully acknowledge Serge Boutet nutritionist and classmate in the support and helping guide line. The authors give a warm thanks to all the companion animal owners for the deep support, comments and observations to provide a successful clinical trial.

The authors give a special thanks to the professionalism of Benoit Choquette Bsc. Agr. and Yvan Giguère from Hagen Pet food products. The authors recognize every help from several professional: Dr Beaudry PhD, Dr Fabricia Vianna DMV, Dr Olivier Gagnon DMV, Dr Cécile Boivin, that provide input to the clinical trial, The authors also thanks the unique contribution of Marie-Hélène Marchand BAA, and all the staff to make this clinical trial possible.

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